Oral / sublingual immunotherapy

Oral / sublingual (SLIT) product

There are also immunotherapies that can be administered sublingually, that is, by squeezing drops under the tongue. Our sublingual product is such a sublingual immunotherapy. It is sufficient to keep a few drops under the tongue for at least 1 minute but preferably 2-3 minutes once every day.

Our sublingual product (SLIT) is intended for people with allergic rhinitis, allergic conjunctivitis and/or allergic asthma. The doctor prescribes the course of treatment on the basis of your specific sensitivity (to grasses, cats or spring trees, for instance). The medication is administered by squeezing drops under the tongue. The purpose of a sublingual treatment is to eliminate your hypersensitivity.  

Our sublingual product is available for a wide range of allergens, allowing individually tailored treatment. The therapy is specifically designed to target the allergen or combination of allergens to which you are sensitive. Consult your doctor or specialist for more information.

Available SUBLIVAC product portfolio (pre-defined mixture):


  • 02-00/02-01: Dermatophagoides pteronyssinus/Dermatophagoides farinae


  • 11-02 : Birch - Betula verrucosa
  • 11-30 : Trees - Corylus avellana, betula verrucosa, alnus glutinosa
  • 07-11 : Grass - Phleum pratense
  • 07-50 : Grasses  - Lolium perenne, poa pratensis, phleum pratense
  • 07-50/07-08 : Grasses + Secale - lolium perenne, poa pratensis, phleum pratense, Secale
  • Triticum sativum

Further allergens for on individual preparation:


  • Quercus robur
  • Fraxinus excelsior
  • Fagus silvatica
  • Olea europea


  • Urtica dioica
  • Plantago lanceolata
  • Artemisia vulgaris
  • Ambrosia eliator
  • Parietaria sp.


  • Aspergillus
  • Alternaria


  • Dog
  • Cat

Summary leaflet: Sublivac®

Composition: Sublivac, sublingual drops, contains allergen extracts that are specifically prescribed for the patient on the basis of a diagnostic examination. Indication: Treatment of IgE-mediated allergy in patients with symptoms of allergic rhinitis, allergic conjunctivitis and/or allergic asthma, caused by allergens. Dosage and administration: The treatment is started with a daily dose of one drop. This dose is then increased every day with one drop until the highest daily dose of five drops is reached. The treatment is continued with five drops. The drops are to be kept under the tongue for at least 1 minute (preferably 2 - 3 minutes) before they are swallowed. The treatment should be continued for 3 to 5 years in order to remain as symptom-free as possible after the completion of the course of treatment. Contraindications: Acute infections of the eye, airways or organs involved in the immune system, secondary changes in the lungs(e.g. lung emphysema or bronchi-ectasie), severe immunopathological diseases or malignancies (e.g. autoimmune diseases of the kidneys, thyroid glands or the nervous system, rheumatism, tuberculosis and HIV), immunodeficiencies (including as a consequence of immunosuppressants), severe uncontrolled asthma with FEV1 under 70%, or hypersensitivity to any of the excipients. Warnings and precautions: If the treatment with pollen extracts is started during the pollen season, there is an increased risk of side effects. Take special care in case of pregnancy, inflammations in the mouth, after tooth extraction and in case of treatment with β-blockers (including ß-blocker containing eye preparations). In the rare case that an anaphylactic shock occurs with the concomitant use of a ß-blocker, adrenaline as a rescue medication can be less efficacious and a higher dose of adrenaline may be required. Severe systemic allergic reactions should be treated with Adrenalin. Side effects: Local reactions in the mouth and throat, stomach upset and diarrhoea. Worsening of allergic reactions such as rhinitis, conjunctivitis, coughing and atopic eczema. Intensified systemic reactions (such as shortness of breath, generalised urticaria or Quincke’s oedema) can develop in rare cases. Intensified allergic reactions can particularly develop in very hypersensitive patients. These symptoms generally arise within 30 minutes after intake of the drops. In individual cases anaphylactic shock has been reported in patients with concomitant asthma. Typical warning signs are burning, itching and heat sensation up and under the tongue, throat and palm of the hand and sole of the foot. Conditions for storage: Store in a refrigerator (2°C - 8°C).When the product is in use, it can be stored for a maximum of 6 months below 25 °C. Package: A SUBLIVAC Initial and maintenance treatment set consists of one bottle with dropper containing 24 ml fluid. 

The complete product information is available upon request. HAL Allergy BV, P.O. Box 1204, 2302 BE Leiden, The Netherlands. Date: July 2013